Bahrain

Although Bahrain currently operates without a national dementia strategy, it provides a uniquely robust home-based care model through the Community Geriatric Psychiatry Service, which deploys multidisciplinary teams to deliver ongoing treatment and caregiver education directly to patients’ homes. To further assist families navigating the strong cultural expectation of informal caregiving, the Ministry of Health offers the Tawasul educational package to help relatives manage complex behavioral and communication challenges. Meanwhile, local researchers at Arabian Gulf University are contributing to global drug discovery efforts by investigating novel enzyme inhibitors designed to target Alzheimer’s-related tau pathology.

Overall
AD Rating
Diagnostic Pathway
The diagnostic pathway begins in primary health centers with general practitioners or family doctors who route patients experiencing memory concerns to secondary or tertiary services, such as Salmaniya Medical Complex or specialised psychiatric and geriatric facilities.
Specialized Care
Bahraini citizens are entitled to free government health coverage under the national healthcare system, which fully finances consultations, specialist care, diagnostic investigations, and approved Alzheimer's medications (including donepezil, rivastigmine, and memantine).
Caregiver Support
Informal carers carry the primary day-to-day caregiving responsibilities amidst strong cultural expectations of family-based care, supported by innovative public initiatives like the Ministry of Health's Tawasul educational package and the multidisciplinary Community Geriatric Psychiatry Service.
National Policies
Bahrain operates without a dedicated national dementia strategy or action plan, addressing cognitive health implicitly through general elder-care legislation (such as Law No. 58 of 2009) and mental health services.
Access to ATT-s
No therapies approved.
Organizations are listed for informational purposes based on publicly available sources. Inclusion does not necessarily indicate affiliation with or endorsement by Alzheimer’s Disease International (ADI).

Highlights

Health system
Universal, Social Insurance (Mixed Provision)
ADI member association(s)
National dementia plan
Dementia plan funding
No plan
Dementia prevalence rate
252
Dementia incidence rate
45
*per 100k Population
Prevalence Rate (per 100,000): 
This measures the total number of existing cases (both old and new) in a population at a specific point in time, divided by the total population and multiplied by 100,000. It tells you the overall "burden" or how widespread a condition is at that moment.
Incidence Rate (per 100,000): 
This measures the number of new cases that develop in a population over a specific period (usually one year), divided by the population at risk and multiplied by 100,000. This tells you the "speed" or risk of contracting the condition.

Population

1,685,552

Median age

33.4

Health expenditure (% of GDP)

3.80

Diagnosis

Bahrain has no dedicated national Alzheimer’s disease diagnostic protocol, with suspected cognitive decline typically progressing from primary care to specialist assessment. Public healthcare for Bahraini citizens generally covers clinically indicated consultations, investigations, CT, and MRI; PET/CT is available through King Hamad University Hospital. The MMSE is used clinically, while MoCA and Trail Making Test have been used in local cognitive research. No credible published data are available on diagnostic waiting times. APOE ε4 has been investigated locally, but routine Alzheimer’s genetic testing is not documented, and CSF amyloid/tau biomarkers are not routinely available for clinical diagnosis.

Diagnosis pathway

Bahrain has no dedicated national Alzheimer’s diagnostic protocol. Suspected cognitive decline is generally assessed first in primary care, followed by referral to psychiatric, geriatric, or other specialist services in the public or private sector. Ministry of Health facilities provide dementia-related psychiatric and geriatric care. Assessment typically incorporates medical and medication history, caregiver observations, cognitive testing, neuroimaging, and laboratory investigations. Cognitive tests assess domains such as memory, attention, language, and problem-solving; MRI or CT helps exclude structural causes, while blood tests investigate potentially reversible contributors, including vitamin deficiencies, thyroid dysfunction, and infections.

Bahrain does not have a dedicated national protocol specifically for Alzheimer’s disease diagnosis. In practice, the diagnostic route in Bahrain follows the same general pattern seen across the Gulf region: patients or their families typically first raise memory concerns with a general practitioner or family doctor at a primary health centre, since Bahrain’s public healthcare system, run by the Ministry of Health, is structured around primary care as the first point of contact before referral to secondary or tertiary services such as Salmaniya Medical Complex. Older people with suspected cognitive decline are referred onward to psychiatric or geriatric specialists; the Ministry of Health explicitly lists psychiatric care for elderly patients, including dementia, at the Psychiatric Hospital, alongside long-term nursing care at Muharraq Geriatric Hospital and outpatient follow-up across Ministry facilities (moh.gov.bh/Services/ElderlyCare). In the private sector, hospitals such as Bahrain Specialist Hospital and Royal Bahrain Hospital run psychiatry departments that see geriatric patients with dementia and related cognitive disorders, while King’s College Hospital London’s Dubai–Bahrain Clinic outlines a more detailed neurocognitive evaluation process for patients in Bahrain. Clinicians review medical history, current medications and behavioural observations reported by family members or carers. This is followed by cognitive testing to measure memory, attention, language and problem-solving, which helps establish the pattern and severity of impairment. Neuroimaging, usually MRI or CT scans, is then used to rule out structural causes such as stroke, tumours or other brain changes, and laboratory blood tests are used to exclude reversible causes of cognitive decline, including vitamin deficiencies, thyroid dysfunction or infections.

Wait times

There is no credible published figure specifically for the interval from GP presentation to specialist dementia assessment, Alzheimer’s disease diagnosis, CT/MRI, or final diagnosis in Bahrain.

Diagnosis cost

Mostly or fully covered

Bahraini citizens generally receive free government healthcare under the Sehati programme, including primary and specialist consultations and clinically indicated diagnostic investigations. CT and MRI are available through the public system, although MRI requires consultant referral.

Citizens are entitled to free government health coverage under the national social health insurance programme, Sehati. Government-funded primary healthcare includes diagnosis and referral to secondary/specialist care when required. GP/family-doctor visits and public-sector specialist care are generally covered for Bahraini citizens, rather than requiring routine consultation copayments. Diagnostic investigations are also covered within the government system when clinically indicated. Bahrain’s public radiology service provides CT and MRI, although expensive investigations such as MRI require referral from a consultant.

Cognitive tests

Available

The Mini-Mental State Examination (MMSE) is used within Bahrain’s healthcare system. There is also evidence of the Montreal Cognitive Assessment (MoCA) and Trail Making Test (TMT) being used in cognitive research conducted at Salmaniya Medical Complex, although this study concerned post-stroke cognitive impairment rather than Alzheimer’s disease specifically.

Imaging tests

Used in specific cases

Computed tomography (CT) and magnetic resonance imaging (MRI) are available in Bahrain’s tertiary healthcare system. The Ministry of Health states that Salmaniya Medical Complex provides both CT and MRI, with these examinations available to outpatients and around the clock for inpatients and emergency patients.

PET/CT is also available in Bahrain, but it is more centralised. Salmaniya Medical Complex does not have its own PET/CT unit; the Ministry of Health states that patients requiring PET/CT are coordinated through King Hamad University Hospital (KHUH). Other published evidence confirms a Nuclear Medicine Department with PET/CT capability at KHUH, and literature describing Bahrain’s tertiary healthcare infrastructure reports PET/CT and PET/MRI at KHUH.

Genetic tests

There is evidence that APOE genotype has been investigated in Bahrain: a Bahrain-based study of cognitive impairment after stroke incorporated the APOE ε4 allele as a potential genetic predictor, demonstrating local capability or access to APOE-related research testing. However, there is no evidence that APOE genotyping or diagnostic sequencing of APP, PSEN1 and PSEN2 is routinely offered specifically for Alzheimer’s disease.

Biomarker tests

Rarely used

Alzheimer’s disease CSF biomarkers — Aβ42, Aβ42/Aβ40, total tau or phosphorylated tau — are not routinely available for clinical diagnosis.

Cognitive Tests

Available

The Mini-Mental State Examination (MMSE) is used within Bahrain’s healthcare system. There is also evidence of the Montreal Cognitive Assessment (MoCA) and Trail Making Test (TMT) being used in cognitive research conducted at Salmaniya Medical Complex, although this study concerned post-stroke cognitive impairment rather than Alzheimer’s disease specifically.

Imaging Tests

Used in specific cases

Computed tomography (CT) and magnetic resonance imaging (MRI) are available in Bahrain’s tertiary healthcare system. The Ministry of Health states that Salmaniya Medical Complex provides both CT and MRI, with these examinations available to outpatients and around the clock for inpatients and emergency patients.

PET/CT is also available in Bahrain, but it is more centralised. Salmaniya Medical Complex does not have its own PET/CT unit; the Ministry of Health states that patients requiring PET/CT are coordinated through King Hamad University Hospital (KHUH). Other published evidence confirms a Nuclear Medicine Department with PET/CT capability at KHUH, and literature describing Bahrain’s tertiary healthcare infrastructure reports PET/CT and PET/MRI at KHUH.

Genetic Tests

There is evidence that APOE genotype has been investigated in Bahrain: a Bahrain-based study of cognitive impairment after stroke incorporated the APOE ε4 allele as a potential genetic predictor, demonstrating local capability or access to APOE-related research testing. However, there is no evidence that APOE genotyping or diagnostic sequencing of APP, PSEN1 and PSEN2 is routinely offered specifically for Alzheimer’s disease.

Biomarker Tests

Rarely used

Alzheimer’s disease CSF biomarkers — Aβ42, Aβ42/Aβ40, total tau or phosphorylated tau — are not routinely available for clinical diagnosis.

Treatment & Care

Bahrain’s dementia care is integrated into geriatric and psychiatric services, with specialist home visits and 24-hour nursing care available, but no documented network of dedicated Alzheimer’s centres. Five Ministry of Health mobile units and community elderly-care centres provide broader home and social support nationwide, although dementia-specific day-care and palliative services remain limited or undocumented. For Bahraini citizens, Alzheimer’s treatment is primarily state-funded, with SEHATI covering eligible chronic-disease treatment and approved medicines. There is no Alzheimer’s-specific caregiver allowance, although disability benefits of BHD 100–200 monthly may apply following formal assessment. The Ministry of Health also provides Tawasul, a dementia-specific education programme supporting families and caregivers.

Specialized facilities and services

Bahrain has specialised dementia services within its geriatric and psychiatric system, but no documented network of dedicated memory clinics or Alzheimer’s centres. The Psychiatric Hospital provides geriatric psychiatry and multidisciplinary home visits for people with dementia aged 65+, while Muharraq Geriatric Hospital offers 24-hour nursing care. Broader elderly-care services include community day centres and five mobile Ministry of Health units covering all governorates, providing home nursing, personal care, and family counselling. However, dedicated dementia day-care and dementia-specific palliative care remain limited or undocumented.

Specialised dementia and Alzheimer’s care. Bahrain has specialist services for dementia within its public geriatric and psychiatric system, rather than a clearly documented network of stand-alone memory clinics. The Ministry of Health identifies a Geriatric Psychiatry Unit at the Psychiatric Hospital, which treats older adults with conditions including dementia and depression. It also provides a community geriatric psychiatry service for people aged 65+, including people with dementia, with multidisciplinary teams making regular home visits. Long-term 24-hour nursing care is available through Muharraq Geriatric Hospital. Thus, specialised dementia care exists, but it is concentrated within a small number of national specialist services rather than distributed through multiple dedicated Alzheimer’s disease centres.

The Ministry of Social Development supervises several elderly day-care centres located in residential communities across the country, providing social, health, psychological, recreational and rehabilitation support, although these are not specifically dementia centres. Home healthcare has particularly broad geographical coverage: the Ministry of Health operates five mobile elderly-care units covering all health regions/governorates, providing nursing, personal care, family counselling and other services at home for people aged 60+ who cannot attend health centres. Dementia patients aged 65+ can additionally receive home visits from the geriatric psychiatry service. This means community and home support is available beyond the main urban hospitals, although dedicated dementia day-care provision is limited.

For people with advanced dementia, relevant long-term and supportive care is available through services such as Muharraq Geriatric Hospital, which provides 24-hour nursing care, alongside hospital, primary-care and home nursing services. However, there is no dedicated dementia-specific palliative-care service.

Approved medication

Generic Name Trade Name Used for
Donepezil Aricept, Aricept ODT, Adlarity, Eranz, Memac, Alzepil, Davia, Donecept, Donep, Donepex, Donesyn, Dopezil, Yasnal, Memorit, Pezale, Redumas, Zolpezil, Namzaric* Donepezil is indicated for the symptomatic treatment of mild to moderately severe Alzheimer’s dementia.
Rivastigmine Exelon, Exelon Patch, Prometax, Rivastach, Nimvastid Symptomatic treatment of mild to moderately severe Alzheimer’s dementia.
Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson’s disease.
Memantine Namenda, Namenda XR, Ebixa, Memary, Axura, Akatinol, Maruxa, Nemdatine, Namzaric* Treatment of adult patients with moderate to severe Alzheimer’s disease.

*Namzaric = combination of Donepezil and Memantine

Treatment cost

Alzheimer’s treatment for Bahraini citizens is primarily state-funded through the public healthcare system. Government hospitals and health centres provide care free of charge, while SEHATI covers chronic-disease treatment and prescribed medicines included in the approved medicines list.

For Bahraini citizens, Alzheimer’s treatment in the public healthcare system is primarily financed by the state. Bahrain’s Ministry of Health states that it provides citizens with free treatment and rehabilitation services, and WHO documentation confirms that healthcare at government hospitals and health centres is free of charge for Bahraini citizens. The national health-insurance law (SEHATI) also provides for coverage of treatment, including chronic-disease treatment, and establishes coverage for prescribed medicines included in the approved medicines list.

Caregiver support

Bahrain has no Alzheimer’s-specific caregiver allowance, although legislation provides broader material and social support for older people and families providing care at home. People with formally assessed disabilities may receive BHD 100–200 per month, depending on severity, but this is a benefit for the person with the disability, not a caregiver payment, and Alzheimer’s does not automatically confer eligibility. The Ministry of Health also offers Tawasul, a dementia-specific family education package covering communication, behavioural difficulties, depression, driving, and caregiver issues.

There is no financial allowance specifically for care partners of people with Alzheimer’s disease in Bahrain. However, Bahrain has broader state programmes for older people and people with disabilities that may indirectly support a family affected by Alzheimer’s disease. Bahrain’s Law No. 58 of 2009 on the Rights of the Elderly explicitly requires the state to provide material, health and social support to older citizens and, importantly, to provide support to families so that they can care for older relatives within the family home. The law does not, however, establish a specific cash payment for an Alzheimer’s disease caregiver.

There is direct financial assistance for disability, which may be relevant if a person with Alzheimer’s disease is formally assessed as having a qualifying disability. Under Bahrain’s disability legislation, eligible people with disabilities receive a monthly disability allowance. Current rules provide BHD 100 per month for disability and BHD 200 per month for severe disability, with severity determined by the Disability Assessment Committee. The money is an entitlement of the person with the disability rather than a salary for the family caregiver, and Alzheimer’s disease does not automatically confer eligibility.

There is also a dementia-specific family education initiative called “Tawasul” (تواصل). The Ministry of Health describes Tawasul as an educational package specifically developed for people with senile dementia and their families. It forms part of a broader set of Ministry resources addressing Alzheimer’s disease, difficult behaviours associated with dementia, communication difficulties, depression, driving and caregiver issues.

Policy

Bahrain has no dedicated national dementia strategy or action plan, and no public development plans have been announced despite calls from medical professionals. Law No. 74 of 2006 allows court-appointed guardianship where legal incapacity is established, potentially limiting autonomy and supported decision-making for people with cognitive impairment, in contrast with Article 12 of the UN CRPD. Dementia awareness is also mixed: a 2025 study found that 42.2% viewed dementia as normal ageing and 24.2% as a mental illness, despite 70.9% correctly defining it. Broader GCC research identifies family reputation, privacy, marriageability concerns, and religious or supernatural interpretations as potential contributors to stigma, although these findings are not dementia-specific.

National dementia plan

Bahrain currently lacks a dedicated national strategy or action plan for Alzheimer’s disease and dementia.

Upcoming plans

While medical professionals have urged action, the government of Bahrain has not publicly announced the development of a national dementia plan.

Policy gaps

Legal barriers

Bahrain permits guardianship when individuals are formally assessed as lacking legal capacity, which may stigmatise people with cognitive impairment by assuming broad incapacity. This contrasts with the CRPD’s supported-decision-making principle, which emphasises individual abilities, preferences, and appropriate support.

In Bahrain’s report to the UN CRPD Committee, the government stated that Bahraini law No. 74 of 2006 treats people with “mental disabilities” as lacking legal capacity and that courts may assign guardianship where official reports establish that a person lacks capacity. Such a system can contribute to stigma when cognitive impairment is treated as global inability rather than assessing what decisions the individual remains able to make and what support could enable them to exercise their own preferences. This contrasts with the supported-decision-making principle in Article 12 of the UN Convention on the Rights of Persons with Disabilities, which Bahrain has ratified.

Cultural barriers

Dementia awareness in Bahrain remains mixed, with a 2025 study finding that 42.2% of respondents viewed dementia as a normal part of ageing and 24.2% as a mental illness, despite 70.9% correctly defining it. Broader GCC research identifies family reputation, privacy, marriageability concerns, and religious or supernatural interpretations as contributors to mental-health stigma. Although not dementia-specific, these factors may influence how cognitive decline is perceived and disclosed in Bahrain.

There is some Bahrain-specific evidence of misconceptions about dementia, although the evidence base remains small. A 2025 Bahrain study on dementia awareness reported substantial confusion among respondents: while 70.9% correctly defined dementia, 42.2% also believed dementia was part of normal ageing and 24.2% viewed it as a mental illness. The “normal ageing” misconception is particularly relevant because it can normalise memory loss and behavioural changes rather than encouraging families to seek diagnosis and treatment.

A recent GCC study including the Gulf states identifies mental-health stigma as being shaped by family honour and reputation, concerns about marriageability, strong family privacy/nondisclosure norms, and religious or supernatural interpretations of psychological distress. Because Bahrain is included within this GCC cultural setting, these mechanisms could influence how families interpret or disclose cognitive decline; however, the study concerns mental illness rather than Alzheimer’s disease specifically.

Research

Bahrain’s NHRA is responsible for clinical trial approval and regulation, but the country has no dedicated public-facing national trial registry, with studies generally registered through international databases such as ClinicalTrials.gov. Arabian Gulf University has contributed to preclinical Alzheimer’s drug-discovery research targeting MARK4, including 2020 work on pyrazolopyrimidine inhibitors and 2025 research on apigenin. These studies remain laboratory-based and do not demonstrate clinical effectiveness.

Selected academic institutions

RCSI Medical University of Bahrain

Clinical trials and registries

The National Health Regulatory Authority (NHRA), specifically through its Clinical Trials & CPD Regulation Section, is the primary body responsible for approving and regulating all clinical trials in the Kingdom. It ensures that all human research methodologies meet strict ethical, legal, and safety protections. Bahrain does not maintain a dedicated, public-facing national registry specifically for patients to search for active clinical trials. Any international interventional studies or major observational studies operating within the country are typically registered on global databases like ClinicalTrials.gov.

Selected innovative methods

Arabian Gulf University researchers have participated in preclinical Alzheimer’s drug-discovery research targeting MARK4, an enzyme implicated in tau phosphorylation. A 2020 study examined pyrazolopyrimidine compounds as MARK4 inhibitors, while a 2025 international collaboration investigated apigenin as another potential inhibitor. These studies represent early-stage laboratory research and do not provide evidence of clinical effectiveness in Alzheimer’s patients.

Researchers at Arabian Gulf University in Manama have collaborated on studies targeting MARK4 (microtubule affinity-regulating kinase 4), an enzyme implicated in tau phosphorylation and therefore relevant to Alzheimer’s pathology. A 2020 study investigated pyrazolopyrimidine compounds as MARK4 inhibitors, using biochemical and computational methods to identify compounds capable of interacting with and inhibiting the enzyme. This is genuinely Alzheimer’s-directed drug-discovery research, although it remains preclinical and the work was an international collaboration rather than a solely Bahraini discovery.

More recently, a researcher from Arabian Gulf University co-authored a 2025 study of apigenin, a naturally occurring flavonoid, as another potential MARK4 inhibitor. The researchers investigated whether blocking MARK4 could offer a route toward reducing Alzheimer’s disease-related molecular pathology. This is early-stage laboratory research — not evidence that apigenin is an effective treatment for Alzheimer’s patients.

Support

Organizations are listed for informational purposes based on publicly available sources. Inclusion does not necessarily indicate affiliation with or endorsement by Alzheimer’s Disease International (ADI).

Bahrain provides free multidisciplinary home-based geriatric psychiatry for people aged 65+, including those with dementia, covering assessment, follow-up treatment, and caregiver education. However, no dedicated media outlet focused exclusively on Alzheimer’s disease or dementia has been identified.

Selected national associations, patient family associations, NGOs:

Selected initiatives

Bahrain’s free Community Geriatric Psychiatry Service provides multidisciplinary home-based dementia assessment, diagnosis, treatment, follow-up, and caregiver education, enabling older people to receive continuing specialist support at home.

Bahrain's Ministry of Health provides the Community Geriatric Psychiatry Service free of charge to citizens and residents aged 65+, including people with dementia. A multidisciplinary team comprising a geriatric psychiatrist, psychiatrist, nurse and social worker conducts regular home visits. The team provides assessment, diagnosis, follow-up treatment and education for both the person and their caregivers, allowing some people with dementia to receive continuing specialist support in their own homes rather than relying entirely on outpatient or institutional care.

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Dedicated media outlets

Bahrain does not have a dedicated media outlet focused exclusively on Alzheimer’s disease or dementia.

Understanding the terms

This section explains key terms used throughout the text to help readers better understand the exploration concepts.
Open Term Glossary
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Contents

Understanding the Terms

Terms used throughout this website are explained below.
A

Amyloid-Targeting Therapies (ATT): A class of disease-modifying treatments, primarily monoclonal antibodies, designed to identify and remove amyloid-beta plaques from the brain to slow cognitive and functional decline in early-stage Alzheimer’s. Examples include Lecanemab and Donanemab.

Aphasia: A language disorder that affects a person’s ability to communicate, often seen early in Frontotemporal Dementia.

APOE ε4 Allele: A genetic variant of the Apolipoprotein E gene that is a major risk factor for late-onset Alzheimer’s disease; while not a causative gene, its presence increases the likelihood of developing the condition.

Acetylcholinesterase Inhibitors: A class of medications, including Donepezil, Rivastigmine, and Galantamine, used to treat cognitive symptoms by increasing levels of chemical messengers in the brain.

Advance Directives (DAT): Legal documents, such as Disposizioni Anticipate di Trattamento in Italy, that allow individuals to specify their future medical treatment and care preferences while they still have the capacity to do so.

Alzheimer’s Disease (AD): The most common cause of dementia, characterized by a progressive neurodegenerative decline caused by the accumulation of amyloid plaques and tau tangles in the brain.

Amyloid-beta Plaques: Protein fragments that build up in the spaces between nerve cells, disrupting communication and triggering immune responses.

Amyloid PET Scan: A specialized nuclear imaging test that uses radioactive tracers to visualize and measure the density of amyloid-beta plaques in the living brain.

Atrophy: The wasting away or shrinking of brain tissue, often measured via MRI to support a clinical diagnosis of dementia or Alzheimer’s.

B

Biomarkers: Measurable biological indicators, such as proteins found in blood or cerebrospinal fluid, used to identify the underlying pathology of a disease.

Blood Biomarkers: Emerging, less-invasive diagnostic tests that measure specific proteins like p-tau or neurofilament levels in blood plasma to detect Alzheimer’s pathology.

C

CSF Analysis (Cerebrospinal Fluid): A diagnostic procedure involving a lumbar puncture to measure levels of tau and amyloid-beta proteins in the fluid surrounding the brain and spinal cord.

CT Scan (Computed Tomography): A diagnostic imaging test using X-rays to create detailed cross-sectional images of the brain; used primarily to rule out other causes of cognitive decline such as tumors or strokes.

Clock Drawing Test (CDT): A brief cognitive screening task where a patient is asked to ask to draw a clock face; it evaluates visuospatial and executive function.

Cognitive Screening: The process of using standardized tests to objectively measure an individual’s mental functions, such as memory, orientation, and attention.

Community-based Care: Healthcare and support services provided within the local community, such as daycare centers, home-based nursing, and local support groups, rather than in institutional settings.

Cube Copying Test: A visuospatial assessment task used during neuropsychological evaluations to test a patient’s ability to replicate geometric shapes.

D

Dementia: An umbrella term for a range of neurological conditions characterized by a decline in memory, language, and thinking skills severe enough to interfere with daily life.

Dementia-friendly Society: A community or national environment where citizens and businesses are trained to understand, respect, and support the needs of people living with dementia.

Disease-modifying Therapies (DMTs): A new class of treatments, such as monoclonal antibodies (e.g., Lecanemab), designed to target the underlying biological causes of Alzheimer’s rather than just managing symptoms.

E

Early-Onset Alzheimer’s: A form of the disease that affects people younger than age 65, often linked to the familial genes.

Executive Function: Higher-level mental skills including planning, focusing, and multitasking; these are often what the Clock Drawing Test evaluates.

F

FDG-PET: A type of PET scan that measures glucose metabolism in the brain to identify patterns characteristic of different dementia subtypes.

Familial Alzheimer’s Disease: A rare, genetic form of the disease linked to mutations in specific genes (APP, PSEN1, PSEN2) that typically presents with early-onset symptoms.

Frontotemporal Dementia (FTD): A type of dementia caused by progressive nerve cell loss in the frontal or temporal lobes, leading to significant changes in behavior, personality, and language.

G

General Practitioner (GP): A primary care physician who acts as the first point of contact and gatekeeper for dementia diagnosis, providing initial assessments and referrals to specialists.

Genotyping: The analysis of an individual’s DNA to identify specific genetic variations associated with dementia risk or causation.

H

Hidden Cost: The indirect economic impacts of dementia, such as the loss of income for family members who must reduce working hours or leave their jobs to provide care.

I

Informal Care / Informal Caregiver: Unpaid care provided by family members, spouses, or friends, which represents the vast majority of long-term support for people living with dementia.

J

Japanese Cognitive Function Test (J-Cog): A specialized cognitive assessment tool used to evaluate mental and functional status in specific research or regional contexts.

L

Lewy Body Dementia (LBD): A type of progressive dementia that leads to a decline in thinking, reasoning, and independent function due to abnormal microscopic deposits that damage brain cells.

Long-Term Care Insurance (LTCI): A specialized branch of insurance, found in systems like Germany and Singapore, that provides financial subsidies for daily living assistance and nursing care.

M

Memory Clinic: A specialized, often multidisciplinary center focused on the expert diagnosis, management, and treatment of dementia and cognitive disorders.

Mild Cognitive Impairment (MCI): An intermediate stage between normal aging and dementia where memory or thinking problems are noticeable but don’t yet prevent daily functioning.

Mini-Mental State Examination (MMSE): A 30-point standardized questionnaire used to measure cognitive impairment by testing orientation, recall, and attention.

Montreal Cognitive Assessment (MoCA): A cognitive screening tool designed to be more sensitive than the MMSE, particularly for identifying Mild Cognitive Impairment.

MRI Scan (Magnetic Resonance Imaging): A non-invasive technology using magnetic fields to produce detailed images of brain structure; used to assess brain atrophy and rule out secondary causes.

N

National Dementia Plan: A formal government strategy outlining a coordinated response to manage dementia diagnosis, care, research, and awareness at a national level.

National Health Insurance (NHI): A government-funded or regulated healthcare system providing universal or subsidized medical services to citizens.

Neuroimaging: The use of advanced techniques, such as CT, MRI, and PET, to visualize the structure and function of the brain for diagnostic purposes.

Neuroinflammation: The brain’s immune response to damage or protein buildup; while initially protective, chronic inflammation can accelerate neurodegeneration.

O

Out-of-Pocket Costs: Direct payments made by patients or their families for medical services, tests, or care that are not covered by insurance or public subsidies.

P

Preclinical Alzheimer’s: The stage where brain changes (like amyloid buildup) are present but no outward symptoms are yet visible.

S

Synaptic Loss: The destruction of synapses (the gaps where neurons communicate), which is often the strongest correlate to cognitive decline.

T

Tau Tangles: Twisted fibers of a protein called tau that build up inside nerve cells, destroying the cell’s transport system.

V

Vascular Dementia: The second most common type of dementia, caused by conditions that block or reduce blood flow to the brain, like strokes.