Slovenia

Research conducted in December 2025

Slovenia is steadily building a dementia-friendly ecosystem that starts with general practitioner-led screening and flows into specialist memory clinics in Ljubljana, while its national Alzheimer Association Spominčica expands a network of Dementia-Friendly Spots across ministries, pharmacies, libraries and local services to support families in everyday life. Guided by the Dementia Management Strategy to 2030, the country is aligning care to modern diagnostics and preparing for next-generation therapies, even as it addresses under-diagnosis and workforce pressures, with public awareness, carer training, telecare at home, and coordinated post-diagnostic support shaping a pragmatic, community-rooted response.

Overall
AD Rating
Diagnostic Pathway
The patient pathway begins with a GP conducting brief cognitive screening (MMSE or MoCA) and basic tests, followed by specialist evaluation with detailed neurological, psychological, and imaging assessments if concerns persist.
Specialized Care
In Slovenia, dementia care costs are driven mainly by home and institutional care (€1,037–€3,369 monthly; €370M+ annually), while standard medications are fully reimbursed, but newer biologics are not covered and require out-of-pocket payment under specialist supervision.
Caregiver Support
Slovenia’s dementia strategy supports caregivers through home and community services, social benefits, and NGO-led programs (Spominčica), though access remains uneven with rural gaps and waiting times.
National Policies
Slovenia’s “Dementia Management Strategy until 2030” establishes a coordinated, multi-stakeholder framework for dementia care, building on the 2017-2020 National Strategy. Key objectives include reducing stigma, promoting prevention, improving early detection, ensuring person-centered care across home, community, and long-term settings, and strengthening post-diagnostic support.
Access to ATT-s
Multiple therapies approved; limited or no reimbursement.
Organizations are listed for informational purposes based on publicly available sources. Inclusion does not necessarily indicate affiliation with or endorsement by Alzheimer’s Disease International (ADI).

Highlights

Health system
Universal, Social Health Insurance, predominantly publicly owned (mixed)
ADI member association(s)
Spominčica – Alzheimer Slovenija
National dementia plan
Dementia Management Strategy in Slovenia until 2030
Dementia plan funding
Funded plan
Dementia prevalence rate
1,369.86
Dementia incidence rate
240.55
*per 100k Population
Prevalence Rate (per 100,000): 
This measures the total number of existing cases (both old and new) in a population at a specific point in time, divided by the total population and multiplied by 100,000. It tells you the overall "burden" or how widespread a condition is at that moment.
Incidence Rate (per 100,000): 
This measures the number of new cases that develop in a population over a specific period (usually one year), divided by the population at risk and multiplied by 100,000. This tells you the "speed" or risk of contracting the condition.

Population

2,117,072

Median age

44.6

Health expenditure (% of GDP)

9.41

Diagnosis

Dementia assessment in Slovenia starts with family doctors performing cognitive screening using MMSE or MoCA, reviewing medications, mood, and daily functioning. Suspected cases are referred to specialized memory clinics at University Medical Centre Ljubljana or University Medical Centre Maribor for detailed neuropsychological testing, MRI and CT imaging, and selective genetic or biomarker evaluations. Functional scans like FDG-PET or SPECT support diagnosis in complex cases. Typical wait times are 3-6 months, with diagnostic costs ranging from €578 to €843 per patient under standardized European test sets.

Diagnosis pathway

A patient’s journey usually begins with a family doctor, who performs brief cognitive screening using tests like the MMSE or MoCA, reviews medications, mood, and daily functioning, and orders basic labs or brain imaging. If concerns remain, specialists conduct detailed neurological, psychological, and imaging assessments.

The first point of contact is the family doctor who performs a preliminary cognitive screen using MMSE (Mini‑Mental State Examination) or MoCA (Montreal Cognitive Assessment), Clock‑Drawing Test, Geriatric Depression Scale (GDS‑15), a review of medications, mood, and functional status (ADL/IADL questionnaires). If symptoms suggest cognitive decline, the general practitioner (GP) orders basic laboratory tests (CBC, thyroid, vitamin B12, metabolic panel) and, if possible, brain computed tomography (CT) or magnetic resonance imaging (MRI). The GP then refers the person to a neurology or psychiatry specialist.
The specialist completes a full neurological and mental status exam, a detailed medical and family history, neuropsychological testing (EADC “uniform test set”: MoCA, RAVLT, Trail Making A/B, Stroop, Boston Naming, WMS subtests), structural imaging (MRI preferred) to exclude secondary pathology).and differential testing for psychiatric disorders (depression, psychosis, anxiety)

Wait times

Long wait time (expected)

At University Medical Centre Ljubljana Memory Clinic, patients typically wait 3-6 months, occasionally up to 9, after referral.

According to the University Medical Centre Ljubljana Memory Clinic peoplse typically wait 3-6 months from primary‑care referral to full cognitive testing and imaging, in some regional cases, up to 9 months.

Diagnosis cost

Partially covered

A cohort at University Medical Centre Ljubljana estimated annual diagnostic costs around €578 per patient, higher for dementia cases. A European comparison using the Uniform Test Set for Dementia Diagnostics reported average diagnostic costs near €843 across Slovenian memory-clinic settings.

A Slovenian memory clinic cohort (UMC Ljubljana) estimated the average annual cost per patient at EUR 578, with higher costs for people ultimately diagnosed with dementia (EUR 751) versus subjective cognitive or mild cognitive impairment (EUR 550) and lower for psychiatric and other disorders (EUR 324). A comparative study of diagnostic costs in three European memory clinic settings found Slovenia’s diagnostic cost using a uniform test set was EUR 843 (771–914). The Uniform test set refers to a standardized diagnostic package (a harmonized group of clinical, neuropsychological, laboratory, and imaging tests) used across several European memory clinics.

Cognitive tests

Available

In Slovenia, dementia diagnosis uses primary-care screening followed by specialized memory-clinic assessment. Doctors apply tools like MMSE and MoCA. Suspected cases are referred to University Medical Centre Ljubljana or University Medical Centre Maribor for comprehensive neuropsychological testing aligned with European Alzheimer’s Disease Consortium standards and national dementia-strategy guidelines.

Imaging tests

Commonly used

Dementia imaging typically begins with MRI, the gold standard at University Medical Centre Ljubljana and University Medical Centre Maribor, identifying brain atrophy and vascular lesions. CT is used when MRI is unavailable. Functional scans like FDG-PET or SPECT help differentiate dementia types and support biomarker-guided treatment decisions.

Genetic tests

National strategy allows selective genetic testing for early-onset dementia or strong family history, via specialists at University Medical Centre Ljubljana Memory Clinic or University Psychiatric Clinic Ljubljana.

Biomarker tests

Rarely used

Slovenia is gradually adopting blood biomarkers alongside imaging and CSF markers. Amyloid PET remains mainly research-based at University Medical Centre Ljubljana Neurology Clinic, while CSF biomarkers support diagnosis in limited cases as new European guidelines and therapies expand biomarker use.

Cognitive Tests

Available

In Slovenia, dementia diagnosis uses primary-care screening followed by specialized memory-clinic assessment. Doctors apply tools like MMSE and MoCA. Suspected cases are referred to University Medical Centre Ljubljana or University Medical Centre Maribor for comprehensive neuropsychological testing aligned with European Alzheimer’s Disease Consortium standards and national dementia-strategy guidelines.

Imaging Tests

Commonly used

Dementia imaging typically begins with MRI, the gold standard at University Medical Centre Ljubljana and University Medical Centre Maribor, identifying brain atrophy and vascular lesions. CT is used when MRI is unavailable. Functional scans like FDG-PET or SPECT help differentiate dementia types and support biomarker-guided treatment decisions.

Genetic Tests

National strategy allows selective genetic testing for early-onset dementia or strong family history, via specialists at University Medical Centre Ljubljana Memory Clinic or University Psychiatric Clinic Ljubljana.

Biomarker Tests

Rarely used

Slovenia is gradually adopting blood biomarkers alongside imaging and CSF markers. Amyloid PET remains mainly research-based at University Medical Centre Ljubljana Neurology Clinic, while CSF biomarkers support diagnosis in limited cases as new European guidelines and therapies expand biomarker use.

Treatment & Care

Specialized dementia care in Ljubljana is provided by the University Medical Centre Ljubljana Memory Clinic and the University Psychiatric Hospital Ljubljana Geriatric Psychiatry Department. Monthly care costs range €1,037-€3,369, with home help and nursing homes representing the largest expenses. Standard Alzheimer’s medications are fully reimbursed by Health Insurance Institute of Slovenia national programs, NGOs such as Spominčica Alzheimer Slovenija.

Specialized facilities and services

Specialized dementia care in Ljubljana is provided by the University Medical Centre Ljubljana Memory Clinic and the University Psychiatric Hospital Ljubljana Geriatric Psychiatry Department, offering neurological and psychiatric services for older adults.

University Medical Centre Ljubljana, Department of Neurology – Centre for Cognitive Impairments (Memory Clinic)

Within the University Psychiatric Hospital Ljubljana, the Geriatric Psychiatry Department provides psychiatric care for older adults, including dementia-related services; cited in national context for dementia care capacities.

Approved medication

Generic Name Trade Name Used for
Donepezil Aricept, Aricept ODT, Adlarity, Eranz, Memac, Alzepil, Davia, Donecept, Donep, Donepex, Donesyn, Dopezil, Yasnal, Memorit, Pezale, Redumas, Zolpezil, Namzaric* Donepezil is indicated for the symptomatic treatment of mild to moderately severe Alzheimer’s dementia.
Official National Product Information
Rivastigmine Exelon, Exelon Patch, Prometax, Rivastach, Nimvastid Symptomatic treatment of mild to moderately severe Alzheimer’s dementia.
Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson’s disease.
Official National Product Information
Galantamine Razadyne, Razadyne ER, Reminyl, Reminyl XL, Nivalin, Lycoremine, Galsya Galantamine is indicated for the symptomatic treatment of mild to moderately severe dementia of the Alzheimer type.
Official National Product Information
Memantine Namenda, Namenda XR, Ebixa, Memary, Axura, Akatinol, Maruxa, Nemdatine, Namzaric* Treatment of adult patients with moderate to severe Alzheimer’s disease.
Official National Product Information
Lecanemab Leqembi Lecanemab is indicated for the treatment of mild cognitive impairment and mild dementia due to Alzheimer’s disease in adult patients that are apolipoprotein E ε4 (ApoE ε4) heterozygotes or non-carriers.
Official National Product Information
Donanemab Kisunla Donanemab is indicated for the treatment of mild cognitive impairment and mild dementia due to Alzheimer’s disease (AD) in adult patients that are apolipoprotein Eε4 (ApoE ε4) heterozygotes or non-carriers.
Official National Product Information

*Namzaric = combination of Donepezil and Memantine

Treatment cost

Monthly informal and social care for dementia patients in Slovenia ranges from €1,037 to €3,369, with formal and informal home help costing €265 million and nursing homes €105 million annually. Diagnostic costs are modest by comparison. Standard Alzheimer’s medications like donepezil, rivastigmine, galantamine, and memantine are fully reimbursed under Health Insurance Institute of Slovenia, while new biologics, such as Kisunla and Leqembi, are not yet covered, leaving patients responsible for these costs. Prescriptions require specialist oversight by neurologists or psychiatrists.

The monthly informal and social care costs for people living with dementia ranged between EUR 1,037 and EUR 3,369. Direct healthcare costs are a smaller portion of total dementia costs, with estimates of EUR 265 million for formal/ or informal home help and EUR 105 million for nursing home accommodation in Slovenia, underscoring that diagnostic costs are modest compared to broader societal care costs.

As of early 2026, Alzheimer’s disease medications in Slovenia are largely covered under the national compulsory health insurance scheme managed by the Health Insurance Institute of Slovenia (ZZZS). Standard cognitive enhancers, including donepezil, rivastigmine, galantamine, and memantine, are listed on the ZZZS positive reimbursement list and are typically reimbursed at 100% of the reference price, meaning people only pay a small co-payment if they opt for a brand-name drug priced above the ZZZS “maximum recognised value.” These medicines must be prescribed by a neurologist or psychiatrist, ensuring specialist oversight in diagnosis and treatment continuation. In contrast, the new biologic Alzheimer’s disease therapies, such as donanemab and lecanemab, though authorised at the European level, are not yet included in Slovenia’s reimbursement list and remain pending national HTA and pricing review. As a result, patients currently bear the full cost of these newer options, while the mainstay generic Alzheimer’s disease medications remain widely accessible through public coverage.

Caregiver support

Slovenia’s National Dementia Strategy recognizes family caregivers as central, promoting home and community support, day and respite centres, and professional training. Caregivers access social benefits under the Long-Term Care Act, while NGOs like Spominčica Alzheimer Slovenija offer counselling, support groups, and the Dementia-Friendly Points network. Home help, day centres, telecare services, and national training programs help caregivers manage daily care, though rural availability remains limited, with waiting times and uneven coverage.

Slovenia’s National Dementia Strategy (2017–2020) recognises family care partners as essential to dementia care. It aims to strengthen home and community support systems, create day and respite centres, and provide professional training for both formal and informal carers.

Carers can receive social support benefits under the Long-Term Care Act (effective 2024), including social security coverage, training, and respite services. Non-governmental organisations (NGOs) like Spominčica Alzheimer Slovenija also provide counselling and support groups.

Home help and dementia-specific day centres exist, mainly in larger cities, offering basic daily assistance and structured programmes. However, service availability remains inconsistent, with limited coverage and long waiting times in rural areas.

The Spominčica’s Dementia-Friendly Points network trains staff across public-facing organisations to support people living with dementia and their care partners; provides local information and post-diagnostic support, backed by the Ministries of Labour and Health.

E-care at home (telecare) project is a nationwide telecare service led by Telekom Slovenije and ZDUS; licensed by the Ministry of Labour; supports older adults and those living with cognitive decline or dementia to live safely at home, reducing carer strain.

National programmes co-financed by the Ministry of Labour and municipalities provide carer training (communication, home care skills, respite options, palliative care).

The DFS network’s growth has been co-funded via Ministry of Health tenders, embedding carer-oriented awareness and support across communities.

Policy

Slovenia’s “Dementia Management Strategy until 2030” provides a multi-stakeholder framework for coordinated, person-centered care, focusing on stigma reduction, prevention, early detection, workforce training, carer support, and research. Implementation includes awareness campaigns, community initiatives like Spominčica Alzheimer Slovenija Dementia-Friendly Points, and updates to clinical pathways and funding models. Legal gaps, limited insurance coverage, uneven Long-Term Care Act implementation, and low public awareness continue to challenge early diagnosis, treatment access, and full realization of national dementia goals.

National dementia plan

Slovenia’s “Dementia Management Strategy until 2030” establishes a coordinated, multi-stakeholder framework for dementia care, building on the 2017-2020 National Strategy. Key objectives include reducing stigma, promoting prevention, improving early detection, ensuring person-centered care across home, community, and long-term settings, and strengthening post-diagnostic support. The strategy emphasizes workforce training, carer support, research, data infrastructure, and governance, including a National Dementia Centre and registry. Implementation is underway for awareness campaigns, workforce development, and community initiatives like Spominčica Alzheimer Slovenija Dementia-Friendly Points, while the 2024–2025 action plan outlines responsibilities, timelines, indicators, and funding to advance these measures and ensure coordinated, evidence-based dementia care nationwide.

The Slovenian government adopted the “Dementia Management Strategy in the country until 2030,” setting an integrated, multi-stakeholder approach and action plans to 2030, with initial actions for 2023–2024.
The current national strategy builds on Slovenia’s earlier National Strategy for Dementia Control (2017–2020), which defined ten areas including awareness, early diagnosis, coordinated care, access to medication, research, surveillance, social care, palliative care, regional multidisciplinary centres, GP cognitive testing, and education for professionals and carers.
The main objectives from Slovenia’s official Dementia Management Strategy until 2030 (Strategija obvladovanja demence v Sloveniji do leta 2030) are to:
• Reduce stigma and raise public awareness about dementia
• Strengthen prevention and risk reduction across the life course
• Improve early detection, diagnosis, and post-diagnostic support
• Ensure timely, coordinated, and person-centred health and social care across settings (home, community, long-term care)
• Develop and support long-term care for people living with dementia, with emphasis on care at home and in local communities
• Establish and maintain a national dementia dataset and registry and improve data, monitoring, and evaluation
• Build workforce capacity: education and training for health, social care professionals, informal carers, and volunteers
• Promote and support research, innovation, and evidence-based practice
• Protect the rights, dignity, and participation of people living with dementia and support carers
• Ensure appropriate care during epidemics and other emergencies, and strengthen system governance (including a National Dementia Centre)

Several elements are already in implementation, while others are in setup phases. Based on official announcements and stakeholder updates, the most advanced areas are action planning, awareness and outreach, workforce training, and steps toward data infrastructure. The government of Slovenia confirmed that the registry and National Dementia Centre are in progress but not yet fully operational.
Furthermore, the government approved the first two-year action plan to implement the 2030 Strategy, detailing measures, responsible bodies, indicators, timelines, funding, and expected results for 2024–2025.
Ongoing national awareness efforts to reduce stigma and community initiatives (e.g., Dementia-Friendly Points6) have been scaled and supported under the strategy framework, which were already active and continue under the new plan.
Continued education and competency-building for health and social care providers and support for informal carers are part of the active implementation, with defined actions in the 2024–2025 plan.

Upcoming plans

The National Institute of Public Health is updating clinical pathways and funding models for dementia therapies, while Spominčica Alzheimer Slovenija Dementia-Friendly Communities expands nationally through 2025-2027.

The National Institute of Public Health confirmed publicly that its technical groups are updating national clinical pathways and financing models for new dementia therapies within the strategic framework 2020–2030.

Led by Spominčica Alzheimer Slovenia in partnership with the Institute of Public Health and municipalities, the Dementia Friendly Communities program is expanding in 2025–2027 beyond pilot towns into a national programme, funded under the Health Promotion and Social Cohesion budget.

Policy gaps

Legal barriers

The dementia registry and National Dementia Centre remain under development, leaving gaps in surveillance, data management, and coordinated care. Outdated guardianship rules, strict data-protection laws, limited insurance coverage for memory-clinic services, and uneven Long-Term Care Act implementation continue to challenge early diagnosis, treatment access, and full realization of Slovenia’s 2020-2030 National Dementia Strategy.

The dementia registry and the National Dementia Centre are still in development, indicating that institutional and regulatory frameworks for surveillance, data management, and coordinated care remain incomplete.

Slovenia’s legal and institutional framework for dementia protection is advanced but faces several regulatory barriers affecting care and early diagnosis. The National Dementia Strategy 2020–2030 acknowledges that outdated guardianship rules still limit supported decision‑making for people living with cognitively impaired, while strict GDPR and national data‑protection laws (ZVOP‑2) slow the integration of the new Dementia Register and data exchange between health and social care. Financially, the current Health Insurance Act does not yet cover multidisciplinary memory‑clinic care or new antibody treatments for Alzheimer’s disease, creating a reimbursement gap that University Medical Centre Ljubljana has highlighted in its system‑impact study. Implementation of the Long‑Term Care Act (2021) remains uneven across municipalities, leaving families to fill support gaps. Together, these legal and administrative constraints continue to delay full realization of Slovenia’s national dementia goals.

Cultural barriers

The WHO European Observatory notes that low public awareness, stigma, and late help-seeking hinder early dementia detection in Slovenia, while studies show adolescents already develop misconceptions and negative attitudes toward Alzheimer’s and dementia patients.

The WHO European Observatory highlights that improving early detection and diagnosis is a major goal because awareness and help‑seeking remain low among the Slovenian population. It links detection barriers with insufficient public awareness and late presentation to clinicians. Hence, early detection remains a challenge, suggesting ongoing societal or cultural reluctance toward dementia screening and diagnosis, possibly due to stigma, lack of awareness, or limited engagement with preventive health services.
In a study of perceptions of a population of adolescents towards patients with Alzheimer’s disease and dementia, they found that adolescents are already forming negative attitudes and misconceptions of dementia.

Research

Researchers at University Medical Centre Ljubljana project introducing lecanemab would strain systems and finances (€1.06 billion/year) while Slovenia advances early-detection (MOPEAD) and precision-medicine (PROMINENT) initiatives.

Clinical trials and registries

Clinical trials in Slovenia are regulated by the Javna agencija Republike Slovenije za zdravila in medicinske pripomočke (JAZMP), which authorizes and oversees study conduct in line with EU Clinical Trials Regulation. Trials are typically registered in international platforms such as the EU Clinical Trials Information System (CTIS) and ClinicalTrials.gov, ensuring transparency and public access to study data.

Selected innovative methods

Researchers at University Medical Centre Ljubljana modeled the national impact of introducing monoclonal antibody therapies like lecanemab, highlighting major system, workforce, imaging, and cost challenges. Treating all eligible patients could cost €1.06 billion annually, exceeding 2022 medication spending. Slovenia also piloted early-detection programs through MOPEAD and participates in the PROMINENT precision-medicine project to improve Alzheimer’s diagnosis and care.

University Medical Centre Ljubljana researchers outline how Slovenian memory clinics would reorganise pathways, capacity, safety monitoring, and costs to introduce therapies like lecanemab. The purpose was to anticipate national system implications of introducing monoclonal antibody treatments (lecanemab and similar) into Slovenia’s public health system, focusing on: diagnostic and care pathways, memory‑clinic capacity and workforce, infusion logistics, imaging, and safety monitoring, and financial affordability and scalability
They estimate substantial system impacts and model national affordability and logistics. More specifically, they find that treating all potential candidates nationwide would cost ≈ €1.06 billion per year, exceeding Slovenia’s entire 2022 national medication spending (€743 million). Even if restricted to high‑priority patients, fiscal impact remains “substantial and likely unsustainable without EU co‑financing or price renegotiation.”

Slovenia served as a regional hub in the Innovative Health Initiative project MOPEAD (Models of patient engagement for Alzheimer’s disease), which piloted innovative ways to find people living with prodromal Alzheimer’s disease and mild Alzheimer’s disease in the community (e.g., web‑based pre‑screening, memory clinic open days, GP routes)

Slovenian partners are involved in PROMINENT, a 5‑year Innovative Health Initiative public‑private project building a digital precision‑medicine platform to improve diagnosis and treatment of neurodegenerative diseases and co‑morbidities.

Support

Organizations are listed for informational purposes based on publicly available sources. Inclusion does not necessarily indicate affiliation with or endorsement by Alzheimer’s Disease International (ADI).

Since 2016, Spominčica Alzheimer Slovenija Dementia-Friendly Spots has built a nationwide network training public-facing staff, running a daily helpline, over 60 Alzheimer Cafés, and national events to raise awareness, reduce stigma, and strengthen care. With no dedicated dementia media in Slovenia, awareness is promoted through mainstream outlets like RTV Slovenija and Spominčica campaigns and documentaries.

Selected national associations, patient family associations, NGOs:

Spominčica – Alzheimer Slovenija

Selected initiatives

Since 2016, Spominčica Alzheimer Slovenija Dementia-Friendly Spots has expanded a nationwide network training public-facing staff to support people with dementia, runs a daily helpline, coordinates over 60 Alzheimer Cafés, and hosts national events to promote awareness, reduce stigma, and strengthen care collaboration.

Dementia Friendly Spots
Since 2016, Spominčica has built a nationwide Dementia Friendly Spots (DFS) network that trains staff in public-facing organisations to recognise and support people living with dementia. The network spans hundreds of locations (ministries, police, pharmacies, libraries, shops, care homes, health centres) and continues to expand, including a DFS at the Ministry of Health in Ljubljana.
Daily Helpline
Spominčica coordinates a daily helpline staffed by clinicians and experts, and expanded DFS activities during COVID-19 with EU co-financed support, producing practical guides and increasing local assistance for families and carers2
Alzheimer Cafes
Slovenia hosts Alzheimer Cafés across more than 60 locations, offering talks by experts and peer support in accessible venues, an initiative widely promoted to raise awareness and reduce stigma 3
National Events
Spominčica convenes national events (e.g., “In the Rhythm of the Human Brain”) bringing together clinicians, ministries, NGOs and patient groups to advance dementia care and policy collaboration

Dedicated media outlets

Slovenia does not have media outlets devoted solely to Alzheimer’s disease and dementia. Instead, coverage appears on mainstream platforms (such as RTV Slovenija) and through the national Alzheimer Association Spominčica’s own channels and collaborations, for example, Spominčica co‑created the prime‑time TV documentary “Facing Dementia” and leads nationwide Dementia‑Friendly Spots campaigns that regularly attract media attention.

Understanding the terms

This section explains key terms used throughout the text to help readers better understand the exploration concepts.
Open Term Glossary
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Contents

Understanding the Terms

Terms used throughout this website are explained below.
A

Amyloid-Targeting Therapies (ATT): A class of disease-modifying treatments, primarily monoclonal antibodies, designed to identify and remove amyloid-beta plaques from the brain to slow cognitive and functional decline in early-stage Alzheimer’s. Examples include Lecanemab and Donanemab.

Aphasia: A language disorder that affects a person’s ability to communicate, often seen early in Frontotemporal Dementia.

APOE ε4 Allele: A genetic variant of the Apolipoprotein E gene that is a major risk factor for late-onset Alzheimer’s disease; while not a causative gene, its presence increases the likelihood of developing the condition.

Acetylcholinesterase Inhibitors: A class of medications, including Donepezil, Rivastigmine, and Galantamine, used to treat cognitive symptoms by increasing levels of chemical messengers in the brain.

Advance Directives (DAT): Legal documents, such as Disposizioni Anticipate di Trattamento in Italy, that allow individuals to specify their future medical treatment and care preferences while they still have the capacity to do so.

Alzheimer’s Disease (AD): The most common cause of dementia, characterized by a progressive neurodegenerative decline caused by the accumulation of amyloid plaques and tau tangles in the brain.

Amyloid-beta Plaques: Protein fragments that build up in the spaces between nerve cells, disrupting communication and triggering immune responses.

Amyloid PET Scan: A specialized nuclear imaging test that uses radioactive tracers to visualize and measure the density of amyloid-beta plaques in the living brain.

Atrophy: The wasting away or shrinking of brain tissue, often measured via MRI to support a clinical diagnosis of dementia or Alzheimer’s.

B

Biomarkers: Measurable biological indicators, such as proteins found in blood or cerebrospinal fluid, used to identify the underlying pathology of a disease.

Blood Biomarkers: Emerging, less-invasive diagnostic tests that measure specific proteins like p-tau or neurofilament levels in blood plasma to detect Alzheimer’s pathology.

C

CSF Analysis (Cerebrospinal Fluid): A diagnostic procedure involving a lumbar puncture to measure levels of tau and amyloid-beta proteins in the fluid surrounding the brain and spinal cord.

CT Scan (Computed Tomography): A diagnostic imaging test using X-rays to create detailed cross-sectional images of the brain; used primarily to rule out other causes of cognitive decline such as tumors or strokes.

Clock Drawing Test (CDT): A brief cognitive screening task where a patient is asked to ask to draw a clock face; it evaluates visuospatial and executive function.

Cognitive Screening: The process of using standardized tests to objectively measure an individual’s mental functions, such as memory, orientation, and attention.

Community-based Care: Healthcare and support services provided within the local community, such as daycare centers, home-based nursing, and local support groups, rather than in institutional settings.

Cube Copying Test: A visuospatial assessment task used during neuropsychological evaluations to test a patient’s ability to replicate geometric shapes.

D

Dementia: An umbrella term for a range of neurological conditions characterized by a decline in memory, language, and thinking skills severe enough to interfere with daily life.

Dementia-friendly Society: A community or national environment where citizens and businesses are trained to understand, respect, and support the needs of people living with dementia.

Disease-modifying Therapies (DMTs): A new class of treatments, such as monoclonal antibodies (e.g., Lecanemab), designed to target the underlying biological causes of Alzheimer’s rather than just managing symptoms.

E

Early-Onset Alzheimer’s: A form of the disease that affects people younger than age 65, often linked to the familial genes.

Executive Function: Higher-level mental skills including planning, focusing, and multitasking; these are often what the Clock Drawing Test evaluates.

F

FDG-PET: A type of PET scan that measures glucose metabolism in the brain to identify patterns characteristic of different dementia subtypes.

Familial Alzheimer’s Disease: A rare, genetic form of the disease linked to mutations in specific genes (APP, PSEN1, PSEN2) that typically presents with early-onset symptoms.

Frontotemporal Dementia (FTD): A type of dementia caused by progressive nerve cell loss in the frontal or temporal lobes, leading to significant changes in behavior, personality, and language.

G

General Practitioner (GP): A primary care physician who acts as the first point of contact and gatekeeper for dementia diagnosis, providing initial assessments and referrals to specialists.

Genotyping: The analysis of an individual’s DNA to identify specific genetic variations associated with dementia risk or causation.

H

Hidden Cost: The indirect economic impacts of dementia, such as the loss of income for family members who must reduce working hours or leave their jobs to provide care.

I

Informal Care / Informal Caregiver: Unpaid care provided by family members, spouses, or friends, which represents the vast majority of long-term support for people living with dementia.

J

Japanese Cognitive Function Test (J-Cog): A specialized cognitive assessment tool used to evaluate mental and functional status in specific research or regional contexts.

L

Lewy Body Dementia (LBD): A type of progressive dementia that leads to a decline in thinking, reasoning, and independent function due to abnormal microscopic deposits that damage brain cells.

Long-Term Care Insurance (LTCI): A specialized branch of insurance, found in systems like Germany and Singapore, that provides financial subsidies for daily living assistance and nursing care.

M

Memory Clinic: A specialized, often multidisciplinary center focused on the expert diagnosis, management, and treatment of dementia and cognitive disorders.

Mild Cognitive Impairment (MCI): An intermediate stage between normal aging and dementia where memory or thinking problems are noticeable but don’t yet prevent daily functioning.

Mini-Mental State Examination (MMSE): A 30-point standardized questionnaire used to measure cognitive impairment by testing orientation, recall, and attention.

Montreal Cognitive Assessment (MoCA): A cognitive screening tool designed to be more sensitive than the MMSE, particularly for identifying Mild Cognitive Impairment.

MRI Scan (Magnetic Resonance Imaging): A non-invasive technology using magnetic fields to produce detailed images of brain structure; used to assess brain atrophy and rule out secondary causes.

N

National Dementia Plan: A formal government strategy outlining a coordinated response to manage dementia diagnosis, care, research, and awareness at a national level.

National Health Insurance (NHI): A government-funded or regulated healthcare system providing universal or subsidized medical services to citizens.

Neuroimaging: The use of advanced techniques, such as CT, MRI, and PET, to visualize the structure and function of the brain for diagnostic purposes.

Neuroinflammation: The brain’s immune response to damage or protein buildup; while initially protective, chronic inflammation can accelerate neurodegeneration.

O

Out-of-Pocket Costs: Direct payments made by patients or their families for medical services, tests, or care that are not covered by insurance or public subsidies.

P

Preclinical Alzheimer’s: The stage where brain changes (like amyloid buildup) are present but no outward symptoms are yet visible.

S

Synaptic Loss: The destruction of synapses (the gaps where neurons communicate), which is often the strongest correlate to cognitive decline.

T

Tau Tangles: Twisted fibers of a protein called tau that build up inside nerve cells, destroying the cell’s transport system.

V

Vascular Dementia: The second most common type of dementia, caused by conditions that block or reduce blood flow to the brain, like strokes.