Switzerland

Research conducted in October 2025

Switzerland combines high-efficiency healthcare, characterised by the low specialist waiting times, with progressive social policies. The country supports families through the unique “Caregiver Employment Model”, which allows relatives to be hired as salaried professionals via the Spitex home care network. This commitment to rights and autonomy extends to the legal sphere in the canton of Geneva, which recently became the first region to grant full voting rights to individuals under guardianship. Additionally, the nation is a hub for diagnostic innovation in the early detection of Alzheimer’s disease.

Overall
AD Rating
Diagnostic Pathway
Switzerland features some of the lowest specialist wait times in the world, with highly efficient memory clinics conducting thorough early-stage assessments.
Specialized Care
A high standard of care is universally accessible through private insurance mandates, ensuring patients receive the latest diagnostic and therapeutic interventions.
Caregiver Support
The "Caregiver Employment Model" is a standout feature, allowing family members to be hired as salaried professionals via home care networks.
National Policies
While care quality is elite, the official National Strategy ended in 2019 and was transitioned into a "Platform," leading to a perceived gap in formal, updated policy documents.
Access to ATT-s
Single therapy approved; no reimbursement.
Organizations are listed for informational purposes based on publicly available sources. Inclusion does not necessarily indicate affiliation with or endorsement by Alzheimer’s Disease International (ADI).

Highlights

Health system
Universal, Private Insurance (Mixed Provision)
ADI member association(s)
Alzheimer Switzerland
National dementia plan
National Dementia Strategy 2014-2019
Dementia plan funding
Funded plan
Dementia prevalence rate
1587
Dementia incidence rate
278
*per 100k Population
Prevalence Rate (per 100,000): 
This measures the total number of existing cases (both old and new) in a population at a specific point in time, divided by the total population and multiplied by 100,000. It tells you the overall "burden" or how widespread a condition is at that moment.
Incidence Rate (per 100,000): 
This measures the number of new cases that develop in a population over a specific period (usually one year), divided by the population at risk and multiplied by 100,000. This tells you the "speed" or risk of contracting the condition.

Population

8,972,534

Median age

42.9

Health expenditure (% of GDP)

11.7

Diagnosis

Alzheimer’s diagnosis follows standardised guidelines from the Swiss Memory Clinics network, starting with GP assessments and referrals to multidisciplinary memory clinics when needed. Evaluations combine cognitive tests (MMSE, Clock Drawing, MoCA), structural imaging (MRI, CT), advanced PET scans for complex cases, and biomarker analyses, including CSF tests and upcoming blood-based p-Tau testing. Genetic testing for early-onset forms requires physician oversight and counseling. Wait times are short, with GP appointments within days and minimal delays for specialist care. Mandatory health insurance covers these diagnostics, with deductibles and co-payments capped, limiting annual out-of-pocket costs to CHF 3,200.

Diagnosis pathway

In Switzerland, Alzheimer’s diagnosis follows standardised guidelines developed by the Swiss Memory Clinics network. Family doctors conduct initial assessments, referring uncertain cases to multidisciplinary memory clinics for comprehensive evaluation using neuropsychological testing, structural imaging, and, when needed, advanced techniques like FDG-PET to ensure diagnostic accuracy.

The diagnostic pathway for Alzheimer’s disease in Switzerland is standardised through diagnostic guidelines developed by the Swiss Memory Clinics association. It begins with a family doctor, who conducts an initial assessment using cognitive screening tools like the MMS and rules out reversible causes for symptoms. If the diagnosis is uncertain, the family doctor refers the patient to a specialist, typically within a dedicated memory clinic. These clinics, organised under the national Swiss Memory Clinics network, use a multidisciplinary team of neurologists, geriatricians, and neuropsychologists for a comprehensive evaluation. The process includes detailed neuropsychological testing to define the cognitive deficits and a structural brain imaging to identify atrophy and exclude other pathologies. Advanced neuroimaging techniques like fluorodeoxyglucose positron emission tomography (FDG-PET) are recommended for patients to clarify unclear dementia etiologies, assess ambiguous cognitive symptoms (including possible non-neurodegenerative causes), and confirm or exclude neurodegeneration through characteristic metabolic patterns.

Wait times

Short wait time (expected)

Switzerland has short wait times, with GP visits within days and among the lowest rates of long specialist appointment delays globally.

Switzerland generally has relatively short waiting times. An appointment with a general practitioner (GP) can typically be secured within two days. Organisation for the Economic Co-operation and Development (OECD) metrics show that Switzerland has the lowest share of patients waiting one month or more for a specialist appointment, compared to other Western countries.

Diagnosis cost

Mostly or fully covered

Mandatory Swiss health insurance covers essential Alzheimer’s diagnostics, including consultations, neuropsychological testing, MRI, CSF and genetic analyses, plus PET imaging. Patients pay deductibles (CHF 300–2,500) and 10% co-payment, capped at CHF 700, totaling maximum annual out-of-pocket costs of CHF 3,200.

Mandatory basic health insurance covers the full range of medically necessary procedures for diagnosing Alzheimer’s disease. This includes consultations with general practitioners and specialists, neuropsychological assessments prescribed by a physician, MRI scans, and biomarker analyses like CSF tests and genetic testing. Advanced imaging, such as FDG-PET and amyloid-PET scans, is also covered. Patients bear initial costs through a mandatory annual deductible (franchise) of their choice, ranging from CHF 300 to CHF 2,500, plus a 10% co-payment on subsequent costs, which is capped at CHF 700 per year. This results in a maximum annual out-of-pocket liability of CHF 3,200 for covered medical services.

Cognitive tests

Available

Mini-Mental-Status-Examination (MMSE) and Clock Drawing Test (CDT) are the most commonly used cognitive screening tests in Switzerland. Other tests, like the Montreal Cognitive Assessment (MoCA) are available and used as well.

Switzerland does not have a national screening programme for the general population for Alzheimer’s disease.

Imaging tests

Commonly used

Structural neuroimaging with Magnetic Resonance Imaging (MRI) and Computed Tomography (CT), as well as Positron Emission Tomography (PET) scanners are available across Switzerland.

In 2021, The Swiss Society of Nuclear Medicine and the Swiss Memory Clinics have jointly published Appropriate Use Criteria for amyloid-PET. These criteria specify that amyloid-PET is most useful for people living with persistent, progressive, and unexplained Mild Cognitive Impairment (MCI), or for individuals who meet the criteria for possible Alzheimer’s disease diagnosis but present with an atypical clinical course or suspected mixed etiology. Also, the introduction of subsidised FDG-PET within Medicare (the publicly funded universal healthcare system in Australia) means the use of FTG-PET is a more common element of diagnostics.

Genetic tests

Testing for Early-Onset Familial Alzheimer’s disease genes (example-APP, PSEN1, PSEN2) is governed by the Swiss Federal Act on Human Genetic Testing, which mandates that such tests be ordered by a physician and be accompanied by comprehensive pre- and post-test genetic counseling. This ensures that patients provide informed consent and receive the necessary support to understand and cope with the results.

Biomarker tests

Analysis of biomarkers in cerebrospinal fluid (CSF) is an established and accessible diagnostic method in specialised Swiss Memory Clinics (both private and public).

Cognitive Tests

Available

Mini-Mental-Status-Examination (MMSE) and Clock Drawing Test (CDT) are the most commonly used cognitive screening tests in Switzerland. Other tests, like the Montreal Cognitive Assessment (MoCA) are available and used as well.

Switzerland does not have a national screening programme for the general population for Alzheimer’s disease.

Imaging Tests

Commonly used

Structural neuroimaging with Magnetic Resonance Imaging (MRI) and Computed Tomography (CT), as well as Positron Emission Tomography (PET) scanners are available across Switzerland.

In 2021, The Swiss Society of Nuclear Medicine and the Swiss Memory Clinics have jointly published Appropriate Use Criteria for amyloid-PET. These criteria specify that amyloid-PET is most useful for people living with persistent, progressive, and unexplained Mild Cognitive Impairment (MCI), or for individuals who meet the criteria for possible Alzheimer’s disease diagnosis but present with an atypical clinical course or suspected mixed etiology. Also, the introduction of subsidised FDG-PET within Medicare (the publicly funded universal healthcare system in Australia) means the use of FTG-PET is a more common element of diagnostics.

Genetic Tests

Testing for Early-Onset Familial Alzheimer’s disease genes (example-APP, PSEN1, PSEN2) is governed by the Swiss Federal Act on Human Genetic Testing, which mandates that such tests be ordered by a physician and be accompanied by comprehensive pre- and post-test genetic counseling. This ensures that patients provide informed consent and receive the necessary support to understand and cope with the results.

Biomarker Tests

Analysis of biomarkers in cerebrospinal fluid (CSF) is an established and accessible diagnostic method in specialised Swiss Memory Clinics (both private and public).

Treatment & Care

Specialised Alzheimer’s care is concentrated in urban centres such as Zurich, Geneva, Basel, Bern, and Lausanne, with rural residents often travelling for services. Support includes Spitex home care, day centres, residential and dementia-focused facilities, and palliative care, though access varies by canton. Mandatory health insurance covers medications, physician-prescribed treatments, and partial transport, while non-drug therapies are largely out-of-pocket. Financial support includes Helplessness Allowance, Supplementary Benefits, and Disability Insurance. Caregivers access Care Credits, salaried Spitex roles, Alzheimer Holidays, and resources from Alzheimer Switzerland and Pro Senectute, including counseling, training, support groups, and the iSupport Swiss app.

Specialized facilities and services

Specialised Alzheimer’s care in Switzerland is concentrated in urban centres like Zurich, Geneva, Basel, Bern, and Lausanne, ensuring strong access there but requiring travel for rural residents. Nationwide, support includes subsidised Spitex home care, day centres, and diverse residential options, including dementia-focused facilities. Palliative care follows national guidelines, yet specialised inpatient services are unevenly distributed and largely urban-based. Integrated models, such as Geneva’s coordinated network, highlight regional disparities, as access to comprehensive, continuous care varies significantly depending on canton of residence.

Specialised memory clinics for Alzheimer’s disease are primarily located in cities with university hospitals, including Basel, Bern, Geneva, Lausanne, and Zurich. While urban residents have good access to high-quality diagnostics, those in rural cantons may face significant travel and potential delays in receiving a comprehensive assessment. For example, Zurich alone hosts 11 memory clinics. In contrast, smaller or less densely populated cantons, like Uri or Graubünden, typically have one or two clinics, often linked to a local hospital. Some alpine or rural cantons (e.g., Schwyz) require residents to travel to neighboring cantons for specialist care.

At-home support is available throughout the country via the subsidised Spitex network for nursing care and private agencies for non-medical help. Day care centres, which offer caregiver respite, are also available, such as the Pilatusblick centre near Lucerne that provides small-group, home-like care. For residential care, options range from traditional nursing homes, many with dedicated dementia wards, to highly specialised, purpose-built centres found in cities like Zurich. Switzerland also hosts a dementia village in Wiedlisbach, designed to fulfill needs of people living with dementia.

Palliative care is available and is guided by the National Guidelines on Palliative Care. Specialised inpatient palliative units offering short-term, acute symptom management are unevenly distributed, and are mostly located within major hospitals in urban centres like Zurich and Geneva. The Geneva Palliative Care Network serves as an exemplary model, coordinating a full range of services from mobile medical teams to social and spiritual support throughout the canton. The existence of such integrated networks is highly dependent on cantonal policy, meaning access to holistic, continuous palliative support varies significantly based on a person’s place of residence.

Approved medication

Generic Name Trade Name Used for
Donepezil Aricept, Aricept ODT, Adlarity, Eranz, Memac, Alzepil, Davia, Donecept, Donep, Donepex, Donesyn, Dopezil, Yasnal, Memorit, Pezale, Redumas, Zolpezil, Namzaric* Donepezil is indicated for the symptomatic treatment of mild to moderately severe Alzheimer’s dementia.
Official National Product Information
Rivastigmine Exelon, Exelon Patch, Prometax, Rivastach, Nimvastid Symptomatic treatment of mild to moderately severe Alzheimer’s dementia.
Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson’s disease.
Official National Product Information
Galantamine Razadyne, Razadyne ER, Reminyl, Reminyl XL, Nivalin, Lycoremine, Galsya Galantamine is indicated for the symptomatic treatment of mild to moderately severe dementia of the Alzheimer type.
Official National Product Information
Memantine Namenda, Namenda XR, Ebixa, Memary, Axura, Akatinol, Maruxa, Nemdatine, Namzaric* Treatment of adult patients with moderate to severe Alzheimer’s disease.
Official National Product Information
Donanemab Kisunla Donanemab is indicated for the treatment of mild cognitive impairment and mild dementia due to Alzheimer’s disease (AD) in adult patients that are apolipoprotein Eε4 (ApoE ε4) heterozygotes or non-carriers.
Official National Product Information

*Namzaric = combination of Donepezil and Memantine

Treatment cost

In Switzerland, mandatory basic health insurance covers approved anti-dementia medications, doctor-prescribed treatments, and up to 50% of necessary transport (capped at CHF 500). Non-drug therapies like music or art therapy are generally excluded, though some supplementary insurance may partially cover them. Patients can access the Helplessness Allowance for daily support, Supplementary Benefits if income is insufficient, and Disability Insurance for pre-retirement diagnoses, aiding with pensions, necessary aids, or home modifications. Alzheimer Switzerland advocates for broader coverage of non-drug interventions to improve access.

Approved anti-dementia medications are covered by the mandatory basic health insurance provided by the government and private nonprofit insurers. Treatments that are explicitly prescribed by a doctor for a recognised medical purpose, such as physiotherapy, are also covered by mandatory basic health insurance, as well as up to 50% of medically necessary transport, capped at CHF 500 per calendar year.

Many beneficial non-drug treatments—such as music therapy, art therapy, and certain forms of specialised psychotherapy—are generally not covered by mandatory basic health insurance. Alzheimer Switzerland is actively campaigning for this to change, as many patients currently cannot access these therapies unless they pay for them privately. Some voluntary supplementary insurance policies may offer partial coverage for these types of therapies, but it depends on the specific plan.

For daily living assistance, patients can apply for a Helplessness Allowance, a non-means-tested cash benefit based on their level of dependency, which can be used to pay for private support. If a patient’s income and assets are insufficient to cover the high costs of care, particularly in a nursing home, they have a legal right to Supplementary Benefits (Ergänzungsleistungen), a means-tested programme that bridges the financial gap. Additionally, for those diagnosed before retirement age, Disability Insurance may provide a pension and cover costs for necessary aids or home modifications. The full list of financial benefits people living with Alzheimer’s disease or other dementia can access can be found on this link: https://www.alzheimer-schweiz.ch/de/ueber-demenz/beitrag/demenzbetroffene-haben-anspruch-auf-finanzielle-unterstuetzung

Caregiver support

Switzerland supports dementia caregivers through programs like Care Credits, salaried Caregiver Employment via Spitex, and Alzheimer Holidays. Organisations like Alzheimer Switzerland and Pro Senectute provide counseling, training, support groups, and digital tools such as the iSupport Swiss app.

Care Credits programme is a non-monetary benefit where a “fictitious income” is credited to the caregiver’s personal state pension account for each year they provide care, protecting their long-term financial security by compensating for career interruptions.

Caregiver Employment Model also directly empowers caregivers by transforming their role into a formal, salaried profession through Spitex agencies, which includes professional training, paid leave, and integration into a specialist support team.

Alzheimer Switzerland organises specialised Alzheimer Holidays that allow both the caregiver and the person living with dementia to take a supported vacation. Alzheimer Switzerland and Pro Senectute serve as points of contact, offering expert counseling, training courses, and local support groups where caregivers can share experiences. The latter also provides digital tools like the iSupport Swiss app to enhance caregiver skills.

Policy

Switzerland’s 2014–2019 National Dementia Strategy promoted awareness, tailored services, professional training, and data sharing. Its successor, the National Dementia Platform, unites 88 organisations for nationwide, individualised support. Legal and cultural gaps remain: voting restrictions for adults under deputyship and limited public understanding, particularly for elderly migrants, sustain stigma.

National dementia plan

Switzerland’s 2014–2019 National Dementia Strategy focused on awareness, needs-based services, professional training, and data sharing. Its successor, the National Dementia Platform, unites 88 organisations to ensure tailored care, support, and treatment nationwide.

National Dementia Strategy (2014–2019) was approved jointly by the federal government and the cantons and it revolved around four main fields of action, each underpinned by specific objectives aimed at improving dementia care and support:

1. Health Literacy, Information & Participation: the goal was to raise public awareness and understanding of dementia and to empower individuals living with dementia and their families to participate actively
2. Needs-Based Services: to provide tailored, integrated support, from early detection and diagnosis to ongoing care, and to promote flexible medico-social offerings attuned to patient needs
3. Quality of Care & Professional Competence: to improve care standards through training and upskilling for healthcare professionals, and to encourage certification and ensure consistent quality across services
4. Data & Knowledge Transfer: to strengthen the exchange of research, best practices, and reliable data, and to enhance planning and policy-making through informed insights

Following the completion of the National Dementia Strategy, the federal government and cantons launched the National Dementia Platform, with a goal to ensure all individuals living with dementia and their caregivers receive care, support, and treatment tailored to their needs. The platform brings together 88 member organisations, encompassing all Swiss cantons as well as national bodies like Alzheimer Switzerland.

Upcoming plans

Currently, there is no plan for a new national Alzheimer’s strategy in the country.

Policy gaps

Legal barriers

Under Swiss federal law, adults under general deputyship cannot vote (Federal Act on Political Rights, Art. 2). Geneva pioneered reform, granting full political rights, aligning with UN CRPD standards, enhancing inclusive participation nationally and locally.

Under Swiss federal law, individuals who are under general deputyship—a form of adult guardianship due to severe mental or physical disabilities—are excluded from voting in national elections. Specifically, Article 2 of the Federal Act on Political Rights stipulates that persons lacking legal capacity, including those under comprehensive guardianship, are ineligible to vote. However, the canton of Geneva has granted full political rights to individuals living with severe mental or physical disabilities. This reform allows people under guardianship to participate in national, cantonal, and communal elections. Geneva became the first Swiss canton to introduce such a reform, aligning with international human rights standards, including the United Nations Convention on the Rights of Persons with Disabilities, which Switzerland signed in 2014.

Cultural barriers

A significant portion of Switzerland’s population lacks dementia knowledge, fueling stigma. Elderly migrants face culturally sensitive care challenges, while the documentary “Alzheimer’s at 56” won the 2024 Anti-Stigma Award.

One study showed that a significant portion of the population in Switzerland lacks comprehensive knowledge about dementia. This knowledge gap may contribute to misconceptions and stigma, as individuals may not understand the symptoms or progression of the disease. A Swiss documentary film “Alzheimer’s at 56 – Family life after the diagnosis” received the Anti-Stigma Award in 2024. There are also unique challenges faced by elderly migrants living with dementia in Switzerland. There is the need for culturally sensitive care that acknowledges the life histories and backgrounds of individuals, ensuring they are not marginalised due to both age and cultural differences.

Research

Researchers in Geneva and Fribourg advance Alzheimer’s diagnostics through multiple avenues: the AMYPAD project studies beta-amyloid via PET, PRETAD examines ethical and clinical aspects of predictive testing, and saliva-based biomarkers enable early risk detection. A European consensus pathway guides individualised diagnostics across 11 phenotypes, while the HUG Memory Clinic validates new blood tests against established CSF and PET standards.

Clinical trials and registries

The Swiss online Brain Health Registry facilitates the registration of people who wish to contribute to research on Alzheimer’s disease and memory-related diseases. Once registered in the registry, they are personally contacted by the researchers at the Centre of their choice and offered the opportunity to participate in a study. The register is open to all persons aged 50 and over, with or without cognitive impairment. After completing a questionnaire, the participant is contacted by a researcher if the criteria he or she has mentioned correspond to the subject of the research.

Additionally, Swiss Clinical Trial Organisation (SCTO) promotes and supports clinical trials in Switzerland, including those related to dementia. They provide information about ongoing trials and resources for researchers. There are Clinical Trial Units (CTUs) at seven hospitals, which have formed a network and thus an established and nationally coordinated clinical research infrastructure.

Selected innovative methods

Geneva and Fribourg researchers advance Alzheimer’s diagnostics through PET and saliva biomarkers, ethical predictive testing studies, and a European consensus pathway, while HUG Memory Clinic validates new blood tests against established CSF and PET standards.

Researchers at University Hospitals of Geneva are involved in various projects, including the AMYPAD project, which focuses on improving the understanding of beta-amyloid proteins as diagnostic and therapeutic markers using PET imaging, and the PRETAD project, which examines the ethical, clinical, linguistic, and legal aspects of predictive testing for Alzheimer’s disease.

A team of researchers at the University of Fribourg has pioneered the investigation of saliva-based biomarkers for the early diagnosis of Alzheimer’s disease. Their research has shown that analysing the microbial flora in saliva can help identify individuals at risk even before the onset of visible symptoms.

A collaborative group from the University of Geneva, Geneva University Hospital, and Italian partners have published a European consensus diagnostic pathway in Lancet Neurology. This tool enables memory clinics to deliver individualised diagnostic strategies, mapping 11 clinical phenotypes and aligning the most appropriate biomarker tests (e.g., lumbar puncture, amyloid/tau PET), thus improving accuracy, reducing unnecessary tests, and preparing for precise therapeutic interventions. The HUG Memory Clinic at the Geneva University Hospitals is a key centre conducting research that directly compares the performance of new blood tests against the established gold standards of CSF analysis and PET imaging.

Support

Organizations are listed for informational purposes based on publicly available sources. Inclusion does not necessarily indicate affiliation with or endorsement by Alzheimer’s Disease International (ADI).

Switzerland provides community-driven dementia support through 150+ Alzheimer Cafés, regional counseling, the Alzheimer-Telefon helpline, alzguide.ch, and the alzpeer digital platform, offering peer support, expert guidance, forums, and podcasts. Alzheimer Switzerland’s website remains the primary dementia information hub.

Selected national associations, patient family associations, NGOs:

Alzheimer Switzerland Spitex Switzerland Pro Senectute

Selected initiatives

Switzerland offers extensive grassroots dementia support, including over 150 Alzheimer Cafés, regional counseling, the Alzheimer-Telefon helpline, alzguide.chdirectory, and the digital alzpeer platform, providing peer support, expert guidance, forums, and podcasts in German, French, and Italian.

Alzheimer Café
At the grassroots level, Switzerland has a strong network of initiatives focused on social health and daily support. A prime example is the Alzheimer Café movement, with over 150 locations providing informal, stigma-free social gatherings for people living with dementia and their families. They provide resources like the Alzheimer-Telefon helpline and the alzguide.ch online directory of services, while the cantonal branches deliver localised support, including counseling and support groups tailored to regional needs.
Alzpeer
Alzheimer Switzerland has also launched alzpeer, the country’s first digital community platform for people living with dementia and their loved ones. Available 24/7 in German, French, and Italian, it combines peer support with expert knowledge, complementing the services of Alzheimer Switzerland’s 21 regional sections. Users can connect one-on-one, join forums or themed groups, access community-recommended resources, and listen to the eight-episode podcast Chopfsach – nachgefragt, featuring expert insights and personal stories.

Dedicated media outlets

Alzheimer Switzerland’s website provides the most extensive information about AD and dementia.

Understanding the terms

This section explains key terms used throughout the text to help readers better understand the exploration concepts.
Open Term Glossary
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Contents

Understanding the Terms

Terms used throughout this website are explained below.
A

Amyloid-Targeting Therapies (ATT): A class of disease-modifying treatments, primarily monoclonal antibodies, designed to identify and remove amyloid-beta plaques from the brain to slow cognitive and functional decline in early-stage Alzheimer’s. Examples include Lecanemab and Donanemab.

Aphasia: A language disorder that affects a person’s ability to communicate, often seen early in Frontotemporal Dementia.

APOE ε4 Allele: A genetic variant of the Apolipoprotein E gene that is a major risk factor for late-onset Alzheimer’s disease; while not a causative gene, its presence increases the likelihood of developing the condition.

Acetylcholinesterase Inhibitors: A class of medications, including Donepezil, Rivastigmine, and Galantamine, used to treat cognitive symptoms by increasing levels of chemical messengers in the brain.

Advance Directives (DAT): Legal documents, such as Disposizioni Anticipate di Trattamento in Italy, that allow individuals to specify their future medical treatment and care preferences while they still have the capacity to do so.

Alzheimer’s Disease (AD): The most common cause of dementia, characterized by a progressive neurodegenerative decline caused by the accumulation of amyloid plaques and tau tangles in the brain.

Amyloid-beta Plaques: Protein fragments that build up in the spaces between nerve cells, disrupting communication and triggering immune responses.

Amyloid PET Scan: A specialized nuclear imaging test that uses radioactive tracers to visualize and measure the density of amyloid-beta plaques in the living brain.

Atrophy: The wasting away or shrinking of brain tissue, often measured via MRI to support a clinical diagnosis of dementia or Alzheimer’s.

B

Biomarkers: Measurable biological indicators, such as proteins found in blood or cerebrospinal fluid, used to identify the underlying pathology of a disease.

Blood Biomarkers: Emerging, less-invasive diagnostic tests that measure specific proteins like p-tau or neurofilament levels in blood plasma to detect Alzheimer’s pathology.

C

CSF Analysis (Cerebrospinal Fluid): A diagnostic procedure involving a lumbar puncture to measure levels of tau and amyloid-beta proteins in the fluid surrounding the brain and spinal cord.

CT Scan (Computed Tomography): A diagnostic imaging test using X-rays to create detailed cross-sectional images of the brain; used primarily to rule out other causes of cognitive decline such as tumors or strokes.

Clock Drawing Test (CDT): A brief cognitive screening task where a patient is asked to ask to draw a clock face; it evaluates visuospatial and executive function.

Cognitive Screening: The process of using standardized tests to objectively measure an individual’s mental functions, such as memory, orientation, and attention.

Community-based Care: Healthcare and support services provided within the local community, such as daycare centers, home-based nursing, and local support groups, rather than in institutional settings.

Cube Copying Test: A visuospatial assessment task used during neuropsychological evaluations to test a patient’s ability to replicate geometric shapes.

D

Dementia: An umbrella term for a range of neurological conditions characterized by a decline in memory, language, and thinking skills severe enough to interfere with daily life.

Dementia-friendly Society: A community or national environment where citizens and businesses are trained to understand, respect, and support the needs of people living with dementia.

Disease-modifying Therapies (DMTs): A new class of treatments, such as monoclonal antibodies (e.g., Lecanemab), designed to target the underlying biological causes of Alzheimer’s rather than just managing symptoms.

E

Early-Onset Alzheimer’s: A form of the disease that affects people younger than age 65, often linked to the familial genes.

Executive Function: Higher-level mental skills including planning, focusing, and multitasking; these are often what the Clock Drawing Test evaluates.

F

FDG-PET: A type of PET scan that measures glucose metabolism in the brain to identify patterns characteristic of different dementia subtypes.

Familial Alzheimer’s Disease: A rare, genetic form of the disease linked to mutations in specific genes (APP, PSEN1, PSEN2) that typically presents with early-onset symptoms.

Frontotemporal Dementia (FTD): A type of dementia caused by progressive nerve cell loss in the frontal or temporal lobes, leading to significant changes in behavior, personality, and language.

G

General Practitioner (GP): A primary care physician who acts as the first point of contact and gatekeeper for dementia diagnosis, providing initial assessments and referrals to specialists.

Genotyping: The analysis of an individual’s DNA to identify specific genetic variations associated with dementia risk or causation.

H

Hidden Cost: The indirect economic impacts of dementia, such as the loss of income for family members who must reduce working hours or leave their jobs to provide care.

I

Informal Care / Informal Caregiver: Unpaid care provided by family members, spouses, or friends, which represents the vast majority of long-term support for people living with dementia.

J

Japanese Cognitive Function Test (J-Cog): A specialized cognitive assessment tool used to evaluate mental and functional status in specific research or regional contexts.

L

Lewy Body Dementia (LBD): A type of progressive dementia that leads to a decline in thinking, reasoning, and independent function due to abnormal microscopic deposits that damage brain cells.

Long-Term Care Insurance (LTCI): A specialized branch of insurance, found in systems like Germany and Singapore, that provides financial subsidies for daily living assistance and nursing care.

M

Memory Clinic: A specialized, often multidisciplinary center focused on the expert diagnosis, management, and treatment of dementia and cognitive disorders.

Mild Cognitive Impairment (MCI): An intermediate stage between normal aging and dementia where memory or thinking problems are noticeable but don’t yet prevent daily functioning.

Mini-Mental State Examination (MMSE): A 30-point standardized questionnaire used to measure cognitive impairment by testing orientation, recall, and attention.

Montreal Cognitive Assessment (MoCA): A cognitive screening tool designed to be more sensitive than the MMSE, particularly for identifying Mild Cognitive Impairment.

MRI Scan (Magnetic Resonance Imaging): A non-invasive technology using magnetic fields to produce detailed images of brain structure; used to assess brain atrophy and rule out secondary causes.

N

National Dementia Plan: A formal government strategy outlining a coordinated response to manage dementia diagnosis, care, research, and awareness at a national level.

National Health Insurance (NHI): A government-funded or regulated healthcare system providing universal or subsidized medical services to citizens.

Neuroimaging: The use of advanced techniques, such as CT, MRI, and PET, to visualize the structure and function of the brain for diagnostic purposes.

Neuroinflammation: The brain’s immune response to damage or protein buildup; while initially protective, chronic inflammation can accelerate neurodegeneration.

O

Out-of-Pocket Costs: Direct payments made by patients or their families for medical services, tests, or care that are not covered by insurance or public subsidies.

P

Preclinical Alzheimer’s: The stage where brain changes (like amyloid buildup) are present but no outward symptoms are yet visible.

S

Synaptic Loss: The destruction of synapses (the gaps where neurons communicate), which is often the strongest correlate to cognitive decline.

T

Tau Tangles: Twisted fibers of a protein called tau that build up inside nerve cells, destroying the cell’s transport system.

V

Vascular Dementia: The second most common type of dementia, caused by conditions that block or reduce blood flow to the brain, like strokes.